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Moreover, ECs induce mutagenic DNA adducts (cyclic 1,N2--hydroxy-propano-deoxyguanosine [-OH-PdG] and O6-methyl-dG) in the mice lungs resulting in DNA damage [85]

Conclusively, in management, we reviewed two international guidelines for smoking cessation by the European Network for Smoking and Tobacco Prevention (ENSP) and the Journal of American College of Cardiology (JACC) (110) (Figures 7, 8)

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